ED Muskoka Physicians - Living the Dream

Aerosol Generating Procedures

https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.15292

Journal of anesthesia 

Purpose of the Study  – Quantify the amount of aerosolization during aerosol generating procedures to inform risk assessment

Study Design

-They monitored aerosolization with continuous sampling with an optical particle sizer, which allowed characterisation of aerosol generation within the zone between the patient and anaesthetist

-The extent to which COVID is transmitted as airborne is controversial 

Problems with the study

-Small sample size – used 4 ORs in the UK

-Only 19 intubations and 14 extubations 

-During intubation they use BVM and not RSI

Conclusion

– Tracheal intubation including facemask ventilation produced very low quantities of aerosolized particles – 500x less than a cough (actually state that “this study does not support the designation of elective tracheal intubation as aerosol generating”.

-Extubation, particularly when the patient coughed, produced a detectable aerosol, 15 folds greater than intubation but 35 folds less than a volatile cough .

Questions– They just say “facemask ventilation” – I think they need to be more specific.  What type of facemask did they use, what was the flow rate?

Take away –

(1)If a break in PPE then chance of acquiring COVID is probably minimal during intubation.

(2) patients coughing on us is more risk than intubation, therefore patient’s properly wearing masks can reduce this.

HALT IT – TXA for GI Bleeds

For this month’s physically distanced Journal Club – a review of the HALT IT trial looking at TXA for GI Bleeds.

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet. 2020; 395(10241):1927-1936.  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30848-5/fulltext

TL;DR:

  • Tranexemic acid (TXA) did NOT reduce 5-day mortality in upper and lower GI bleed patients.
  • It did show small increase risk of VTE.
  • Well designed, large trial. Best evidence to date for TXA in GI bleed.

Background:

  • GI bleeds have a high mortality rate (10%)
  • TXA is an antifibrinolytic agent that has been shown to be effective at preventing bleeding complications in a variety of settings (surgery, trauma, epistaxis)
    • We love it for its low cost, minimal SE profile, and numerous indications in the ER
  • A 2012 Cochrane Review for UGIB showed a reduction in all-cause mortality with TXA for GI bleeds
    • However, individual trials were small and prone to biases making it difficult to draw definitive conclusions… but was the best evidence we had until now

Clinical Question:

  • Does IV tranexamic acid reduce 5-day death due to bleeding?

Methods:

  • International, multi-centre, randomized, double-blind, placebo controlled trial (15 countries, 164 hospitals)
  • Intervention:
    • 1g TXA IV over 10 min the 125mg/hr x 24 hours (3g) vs. Placebo

Patients:

  • Adults (>16/18 yo depending on country)
  • With “significant” acute GI bleeding
    • Risk of bleeding to death:  
      • Hypotension
      • Tachycardia
      • Signs of shock
      • Likely to need transfusion, urgent endoscopy or surgery
  • Treating clinician had to be “substantially uncertain” about whether to use TXA

Outcome:

  • Primary outcome: death due to bleeding at 5 days
  • Secondary outcomes:
    • Death due to bleeding at 24 h and 28 d randomization
    • All cause and cause specific mortality at 28d
    • Rebleed (24h, 5d, 28d)
    • Blood product transfusion
    • MI/CVA
    • VTE (DVT/PE)
    • Seizures
    • Days in the ICU
    • Functional status in-hospital or at 28d
    • Other (cardiac events, sepsis, pneumonia, resp failure, renal failure, liver failure)

Results:

  • Patients:
    • 12 009 patients enrolled
    • 65% male, mean age 58
    • the mean time from bleeding onset to randomization was 22 hours
      • only 16% of patients presented within 3 hours
    • 89% had upper GI bleeding
    • 45% suspected to have variceal bleeds
    • 60% showed NO signs of shock at enrolment
  • NO BENEFIT
  • Primary outcome:
    • Death due to bleeding at 5 days = 3.7% (n=222) of TXA group and 3.8% (n=226) of placebo group (RR 0.99, 95% CI 0.82-1.18)
  • Secondary outcomes:
    • All cause mortality at 28 days (9.5% of TXA group and 9.2% of placebo group, RR 1.03, 95% CI 0.92-1.16)
    • No difference in rebleeding, surgery, endoscopy, need for transfusion, or total blood products transfused
    • RISKS – doubling of venous thromboembolic events (0.4% placebo and 0.8% TXA (RR 1.85, 95% CI 1.15-2.98)
    • NNH = 250

Limitations:

  • The authors changed the primary outcome from “all-cause mortality” to “death due to bleeding at 5d”
    • Not entirely sure why, as “all cause mortality” is clinically more relevant to us, “death” vs “death from bleeding” are one and the same when talking to family members
    • However, the change of this primary outcome forced the authors to increase their sample size by 4000, and still powered the study to detect a difference in the original outcome
  • The majority of patients in the trial had variceal bleeding due to liver disease and accounted for 75% of deaths, but also increased risk of VTE was more pronounced in patients with liver disease
  • Only 9% of patients were on anticoagulants, so unsure of applicability of data to that group

Thoughts:

  • Overall really well done study, very few protocol violations, excellent follow up
  • Time to randomization was high (mean ~ 22hrs)
    • Looking back at CRASH-2 showed mortality benefit (>20 000 pts, 4.9% vs 5.7% (p = 0.0077)) when 1g TXA given <3 hrs, but not after that.
    • Perhaps we would have been benefit it TXA was administered earlier in GI bleed patients
    • However, if these patients don’t present to us within that time frame, there is no point seeing if TXA works for GI bleeds if given in <3hrs
  • Since CRASH2 there has been lots of interest in TXA, but multiple studies since this positive publication have failed to show similar benefit from TXA
    • TICH -2 – no difference in mortality or neurological outcomes with TXA and ICH (Sprigg 2018)
    • WOMAN no difference in mortality or hysterectomy in PPH (WOMAN 2017) (*revised primary outcome, “death due to PPH” showed small benefit, NNT 267, but fragility index 0…, so overall not a resounding “positive study” in my opinion)
    • CRASH3 – no difference in mortality or neurologic outcomes in TBI (CRASH 2019)
    • Important to have these negative studies published given the well known publication bias of only positive studies
  • Not entirely clear why they had the inclusion criteria of “clinician substantially uncertain whether to use TXA”
    • How do we know if our gestalt is correct if we eliminated those patients from the trial?
    • Perhaps this is mostly to include obvious criteria such as allergy, or for ethical reasons for clinicians to be able to treat patients to the best of their ability, but it is hard to know how many patients were not included and if that would have had any effect on the outcome

Take Home Thoughts:

  • Despite some of the study weaknesses, this is a very well-designed, large trial, and a “negative” trial of this magnitude is clinically important.
  • Based on the current evidence, I will not be using TXA in the management of the GI bleed patients
  • What are you thoughts? Does this change your clinical practice?

References:

  1. Crash-2 Collaborators. (2011). The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. The Lancet377(9771), 1096-1101.
  2. Dewan, Y., Komolafe, E. O., Mejía-Mantilla, J. H., Perel, P., Roberts, I., & Shakur, H. (2012). CRASH-3-tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials13(1), 1-14.
  3. Gluud, L. L., Klingenberg, S. L., & Langholz, E. (2012). Tranexamic acid for upper gastrointestinal bleeding. Cochrane Database of Systematic Reviews, (1).
  4. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet. 2020; 395(10241):1927-1936. 
  5. Justin Morgenstern, “TXA for GI bleeds”, First10EM blog, March 9, 2020. Available at: https://first10em.com/txa-for-gi-bleeds/.
  6. Roberts, I., Shakur-Still, H., Afolabi, A., Akere, A., Arribas, M., Brenner, A., … & Jairath, V. (2020). Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet395(10241), 1927-1936.
  7. Salim Rezaie, “REBEL Cast Ep85: The HALT-IT Trial – TXA in Acute GI Bleeds”, REBEL EM blog, June 27, 2020. Available at: https://rebelem.com/rebel-cast-ep85-the-halt-it-trial-txa-in-acute-gi-bleeds/.
  8. Shakur, H., Elbourne, D., Gülmezoglu, M., Alfirevic, Z., Ronsmans, C., Allen, E., & Roberts, I. (2010). The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials11(1), 40.
  9. Sprigg, N., Flaherty, K., Appleton, J. P., Salman, R. A. S., Bereczki, D., Beridze, M., … & Dineen, R. A. (2018). Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. The Lancet, 391(10135), 2107-2115.

Atrial Fibrillation: Pharmacological vs Electrical

Hey guys. Hopefully better late than never! I am on virtual Journal Club this month. Thanks Pierre for the reminder.

In the busy Muskoka ED department. Patients coming in with atrial fibrillation requiring cardioversion. Chemical vs Electrical vs combination of both. Which option allows for the best outcome and what allows for me to keep the best flow in the department?

Electrical versus pharmacological cardioversion for emergency department patients with acute atrial brillation (RAFF2):
a partial factorial randomised trial

Lancet 2020; 395: 339–49

The Question:

  1. compare the sinus conversion of pharmacological cardioversion followed by electrical cardioversion to electrical cardioversion along
  2. effectiveness anteroposterior vs anterolateral pad placement

Methods:
Group 1: procainamide 15mg/kg (max 1500mg over 30min) wait 30minutes and then electrical cardioversion vs placebo infusion and then electrical cardioversion. Around 200 patients assigned to each group.

Results:
96% of patients in drug-shock group converted vs 92% in the shock group. 52% in the drug shock group converted after infusion (in the drug-shock group) and 9% after the placebo infusion.

Adverse events: transient hypotension more common in the drug-shock group (resolved with fluids) and one cardiac arrest in the shock only group (not synchronized cardioversion)

Time in the ED:
Similar in both groups (however, electrical cardioversion received placebo infusion, so likely not accurate representation)

For Pad placement: no different between anteroposterior vs anterolateral.

For more intense analysis of the article check out RebelEM: https://rebelem.com/raff2-electrical-vs-pharmacological-cardioversion-for-ed-patients-with-acute-atrial-fibrillation/

Question:
So… would you use procainamide infusion and potentially save 50% of the Afib procedural sedations in the department?

Hypertension in the Emergency Department

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facesheets

Please everyone look at the two options that cerner is pushing on us for an ED factsheet.

Both er’s have copies of them for you to look at and a binder for you to write your name and comments in. Deadline for feedback is oct 11.

Please speak up or forever hold your peace. Write your thoughts .

Write your suggested modifications.

These options are getting forced on all hospitals that bought cerner.

Reactivate clinic

Dr Rich Trenholm would like to consider presenting or talking to our ed groups to tell him what his clinic has to offer for patients ( sports med consult with him or Dr Pierre Mikhail, chiro, massage, physio, etc).

I think many of us know what is at the clinic and that sports med related referrals can be ohip covered with a referral but I am just reaching out on his behalf to the group of there is interest in a discussion.

Let me know if you are interested. depending on interest then he will decide how to efficiently meet/discuss/plan)

Huntsville ER

Anyone upset if the fixed mount computer in the trauma room is removed as this has been suggested by nursing leadership?

Never gets used, taking up space and hope to use elsewhere!

A WOW gets pulled in whenever needed and is preferable to the nurses.

Just asking before pulled.

Barrie cardio visit

Hi all, Anyone interested in joining me and Sanjay Jindal on oct 8th at Three guys and a Stove? I think 6 or 6:30pm start for dinner and discussion with cardiology from RVH! To hear the update of their program and understand when they are online for STEMI’s, etc!! Numbers capped at about 10.
first to sign up will be in! text or email direct to me.

SMMH er shifts

Hi all,

Please send me an email confirming what shifts you picked up in July that qualified for the incentive . I need confirmation from each of you this applies too to try and get pay aug 15th from hospital and to let Liz Coombs know.

ALSO – last two shifts not covered in august in SMMH aug 25th and aug 26th nights!! If night doesn’t worked for you then we can try and swap things around!! Both qualify for the $500 incentive per shift too of coarse!!

I have talked to many, many locus about these and no luck so far…

ectas

If you have a concern with a etas level then please send the mrn, initials and visit day to carmen.shakespeare@mahc.ca or scan the facesheet to her . She has taken Leslie Secords role and is actively looking at how we can use/modify/educate around ectas to make cats levels more in line with what is practical for the patient.

The nurses or us can send information to Carmen so please don’t just complain about the ctas levels try and do something about it.